SYK: Spleen Tyrosine Kinase (SYK) is an intracellular, non-receptor cytoplasmic protein tyrosine kinase. It serves as a key mediator of Fc and B cell receptors that produce signals in inflammatory cells including macrophages, neutrophiles, master cells, NK cells and B cells.
FLT3: Mutations within the FMS-like tyrosine kinase 3 (FLT3), a class III receptor tyrosine kinase (RTK) family gene on chromosome 13q12, have been detected in up to 35% of acute myeloid leukemia (AML) patients. FLT3 mutations represent one of the most frequently identified genetic alterations in AML.
LRRK2: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset autosomal dominant familial Parkinson’s disease (PD) and also contribute to idiopathic PD.