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IR/PR Materials
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Jan 22, 2019IR/PRClinical Cancer Research: YH25448, an Irreversible EGFR-TKI with Potent Intracranial Activity in EGFR Mutant Non–Small Cell Lung Cancer
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Jun 01, 2018IR/PRASCO 2018: YH25448, a 3 rd Generation EGFR TKI, in Patients with EGFR TKI resistant NSCLC: Phase I/II Study Results
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Apr 14, 2018IR/PRAACR 2018: YH25448, an irreversible 3rd-generation EGFR TKI, exhibits superior anticancer effects with potent brain BBB penetration in NSCLC
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Jan 12, 2017IR/PRCancer Research: Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer
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Dec 07, 2016IR/PRIASLC 2016: YH25448, a highly selective 3rd generation EGFR TKI, exhibits superior survival benefit over osimertinib in mice with brain metastases of NSCLC
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Oct 06, 2016IR/PRCrystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs